Most synthetic cannabinoids are agonists with the cannabinoid receptors. They have been designed to be much like THC,[9] the pure cannabinoid Using the strongest binding affinity into the CB1 receptor, that is connected to the psychoactive outcomes or "high" of cannabis.[10] These synthetic analogs frequently have higher binding affinity and larger potency into the CB1 receptors.
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These merchandise are also referred to as liquid incense. Spray is usually made use of with The mix of both in alternative ways. Several products can be found in the industry-relevant to it.
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[eighty five] HU-210 can be a chiral compound to start with synthesized by Raphael Mechoulam at Hebrew University in the eighties. It absolutely was identified in herbal incense solutions with the U.S. Customs and Border Safety in January 2009; nonetheless, classical cannabinoids are rarely witnessed in synthetic cannabinoid blends for leisure use, probably simply because they are challenging to synthesize.[86]
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K2 spray operates by applying artificial cannabinoids to the floor, for instance paper or herbs. The moment sprayed, the artificial compounds are absorbed via the medium and might afterwards be consumed by several procedures, including smoking or vaporizing.